Escaflowne

Escaflowne, the God Protector of Fanelia, has been stolen and the country is left in ruins. Desperate to find the key to Escaflowne's seal and recover the legendary guymelef, Van Fanel, Prince of Fanelia is sent to Earth, only to find it in the possession of a high school girl, Hitomi Hoshino. With enemies chasing them at every turn, can the two reclaim what was lost?

Named Messiah Knight when serializing in Monthly Asuka Fantasy DX, but renamed to HITOMI when tankoubon were published.